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Duncan L Mcvey

from Derwood, MD
Age ~67
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Related to:
Marshall S Mcgill, 50Vanessa A Mcneill, 56Arnetta M MoffattDenzil M Peirce, 31Brendan Mckiernan, 78Anne M MckinzieSam Mcvey, 29
Connected to:
Amy M Mcvey, 46Andy R Mcvey, 29Brady A Mcvey, 28Carolyn Mcvey, 52Casey E Mcvey, 63Cheryl Mcvey, 52Christopher L Mcvey, 51David L Mcvey, 81Debra M Mcvey, 72Ella B Mcvey, 86

Duncan Mcvey Phones & Addresses

  • 6016 Muncaster Mill Rd, Derwood, MD 20855 (301) 208-1392
  • Rockville, MD
  • West Lafayette, IN
  • Princeton, MN
  • Circle Pines, MN
  • Saint Paul, MN
  • Syosset, NY
  • W Lafayette, IN

Resumes

Resumes

Duncan Mcvey Photo 1

Associate Director

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Location:
Derwood, MD
Industry:
Pharmaceuticals
Work:
Bristol-Myers Squibb
Associate Director
Bristol-Myers Squibb
Principal Scientist
Genvec 1993 - 2013
Scientist Iii
Molecular Genetics 1983 - 1984
Technitian
Education:
Stony Brook University 1990 - 1990
Doctorates, Doctor of Philosophy, Genetics, Philosophy Purdue University 1982 - 1982
Bachelors, Bachelor of Science, Biology, Chemistry
Skills:
Research Funding
Data Driven Decision Making
Patent Applications
Identify New Product Opportunities
Supervisory Responsibilities
Publication In Peered Reviewed Journals
Duncan Mcvey Photo 2

Duncan Mcvey

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Duncan Mcvey Photo 3

Duncan Mcvey

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Duncan Mcvey Photo 4

Sr. Scientist At Genvec

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Position:
Biologist at GenVec
Location:
Washington D.C. Metro Area
Industry:
Biotechnology
Work:
GenVec
Biologist

Publications

Wikipedia References

Duncan Mcvey Photo 5

Duncan Mcvey

About:
Born:

Bailleston, Glasgow , Scotland

Died:

2010 • Wellington , New Zealand

Work:

Duncan McVey " Duncan Joseph McVey " is a former association football player who represented New Zealand national football team at international level.

Education:

McVey made a solitary official international appearance for New Zealand in a 4-1 win over New Caledonia national football team on 2 June 1962, McVey and Trefor Pugh scoring twice each for New Zealand.

Skills & Activities:
Sport:

New Zealand association football player • New Zealand international football player • Football

Wikipedia

Duncan McVey

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Duncan Joseph McVey is a former football (soccer) player who represented New Zealand at international level. McVey made a solitary official international ...

Us Patents

Chimeric Vectors Comprising A Phage Packaging Site And A Portion Derived From The Genome Of A Eukaryotic Virus

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US Patent:
6440728, Aug 27, 2002
Filed:
Nov 30, 1999
Appl. No.:
09/450972
Inventors:
Duncan L. McVey - Derwood MD
Douglas E. Brough - Olney MD
Mohammed Zuber - Frederick MD
Imre Kovesdi - Rockville MD
Assignee:
GenVec, Inc. - Gaithersburg MD
International Classification:
C12N 1563
US Classification:
4353201, 435477, 536 231
Abstract:
The present invention provides an improved method of making eukaryotic gene transfer vectors comprising homologous recombining lambdid vectors with a second DNA in a bacterium to generate novel recombinant eukaryotic viral gene transfer vectors as well as a novel lambdid vector used in the inventive method and an inventive system comprising the novel lambdid vector.

Plasmids For Construction Of Eukaryotic Viral Vectors

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US Patent:
6475757, Nov 5, 2002
Filed:
Jul 13, 2001
Appl. No.:
09/905758
Inventors:
Duncan L. McVey - Derwood MD
Douglas E. Brough - Olney MD
Imre Kovesdi - Rockville MD
Assignee:
GenVec, Inc. - Gaithersburg MD
International Classification:
C12N 1563
US Classification:
435 9141, 4353201, 435455, 435456, 435 5, 435 6, 435 914, 435 9152, 435 911, 435463
Abstract:
The present invention provides a dual selection cassette (DSC) comprising first and second DNA segments having homology to a eukaryotic viral vector, positive and negative selection genes, each operably linked to their own promoter, and one or more unique restriction enzyme sites (URES) or sitey-directed homologous recombination sites. The present invention also provides a plasmid, pN/P, comprising an independent positive selection marker gene, an origin of replication, and a dual selection cassette. The dual selection cassette and pN/P plasmid can be used to produce eukaryotic gene transfer vectors without requiring temporally-linked double recombination events or the use of specialized bacterial strains that allow the replication of plasmids comprising defective origins of replication. This method usefully increases the ratio of desired to undesired plasmid and vector constructs. Additionally, this invention provides a method for the creation of eukaryotic viral vector libraries.

Rca-Free Adenoviral Vector System And Propagation Method

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US Patent:
6482616, Nov 19, 2002
Filed:
May 27, 1999
Appl. No.:
09/321797
Inventors:
Imre Kovesdi - Rockville MD
Douglas E. Brough - Olney MD
Duncan L. McVey - Derwood MD
Joseph T. Bruder - New Market MD
Alena Lizonova - Rockville MD
Assignee:
GenVec, Inc. - Gaithersburg MD
International Classification:
C12N 510
US Classification:
435 914, 4353201, 435325, 435366, 435456
Abstract:
The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.

Method Of Preparing A Eukaryotic Viral Vector

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US Patent:
6573092, Jun 3, 2003
Filed:
Oct 10, 2000
Appl. No.:
09/685914
Inventors:
Imre Kovesdi - Rockville MD
Duncan L. McVey - Derwood MD
Assignee:
GenVec, Inc. - Gaithersburg MD
International Classification:
C12N 1580
US Classification:
4353201, 435 9133, 435 9132, 435 9141, 435 9142, 435 914, 435325, 4241991, 4242051, 4242331
Abstract:
The inventive method of producing a eukaryotic viral vector comprises contacting a eukaryotic cell, which comprises a unique enzyme that nicks or cleaves a DNA molecule, with a recombinant phage vector, or contacting a eukaryotic cell, which does not comprise a unique enzyme that nicks or cleaves a DNA molecule, simultaneously or sequentially, in either order, with (i) a unique enzyme that nicks or cleaves a DNA molecule, and (ii) a recombinant phage vector. The recombinant phage vector comprises the DNA molecule comprising (a) a eukaryotic viral vector genome comprising a coding sequence, (b) a phage packaging site that is not contained within the eukaryotic viral vector genome, and (c) a promoter that is operably linked to the coding sequence. The DNA molecule enters the eukaryotic cell, and the unique enzyme nicks or cleaves the DNA molecule in the eukaryotic cell in at least one region not contained within the eukaryotic viral vector genome, thereby inducing the production of and ultimately producing a eukaryotic viral vector.

Viral Vector Encoding Pigment Epithelium-Derived Factor

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US Patent:
6821775, Nov 23, 2004
Filed:
Jun 23, 2000
Appl. No.:
09/599997
Inventors:
Imre Kovesdi - Rockville MD
Douglas E. Brough - Olney MD
Duncan L. McVey - Derwood MD
Lisa Wei - Gaithersburg MD
Assignee:
GenVec, Inc. - Gaithersburg MD
International Classification:
C12N 15861
US Classification:
4353201
Abstract:
The present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof. The nucleic acid sequence is operably linked to regulatory sequences necessary for expression of PEDF or a therapeutic fragment thereof. Preferably, the viral vector is an adenoviral vector or an adeno-associated viral vector. Also preferably, the viral vector further comprises one or more additional nucleic acid sequences encoding therapeutic substances other than PEDF.

Method Of Preparing A Eukaryotic Viral Vector

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US Patent:
6908762, Jun 21, 2005
Filed:
Apr 30, 2003
Appl. No.:
10/427759
Inventors:
Imre Kovesdi - Rockville MD, US
Duncan L. McVey - Derwood MD, US
Assignee:
GenVec, Inc. - Gaithersburg MD
International Classification:
C12N015/80
C12N015/861
C12N015/87
C12N015/90
C12N015/86
US Classification:
4353201, 435 9133, 435 9132, 435 9141, 435 9142, 435 914, 435325, 4351991, 4241991, 4242331, 4242051
Abstract:
The inventive method of producing a eukaryotic viral vector comprises contacting a eukaryotic cell, which comprises a unique enzyme that nicks or cleaves a DNA molecule, with a recombinant phage vector, or contacting a eukaryotic cell, which does not comprise a unique enzyme that nicks or cleaves a DNA molecule, simultaneously or sequentially, in either order, with (i) a unique enzyme that nicks or cleaves a DNA molecule, and (ii) a recombinant phage vector. The recombinant phage vector comprises the DNA molecule comprising (a) a eukaryotic viral vector genome comprising a coding sequence, (b) a phage packaging site that is not contained within the eukaryotic viral vector genome, and (c) a promoter that is operably linked to the coding sequence. Alternatively, the DNA molecule is not present within the recombinant phage vector. The eukaryotic cell is contacted with the first DNA molecule and a recombinant phage vector.

Methods Of Preparing And Using A Viral Vector Library

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US Patent:
6998263, Feb 14, 2006
Filed:
Feb 9, 2001
Appl. No.:
09/780526
Inventors:
Imre Kovesdi - Rockville MD, US
Duncan L. McVey - Derwood MD, US
Thomas J. Wickham - Germantown MD, US
Joseph T. Bruder - Ijamsville MD, US
Douglas E. Brough - Olney MD, US
Assignee:
GenVec, Inc. - Gaithersburg MD
International Classification:
C12N 15/63
C12N 7/01
US Classification:
4353201, 4352351, 435DIG 22, 435DIG 23, 536 231, 536 241
Abstract:
The present invention provides a library of viral vectors, wherein each member comprises a first heterologous DNA encoding a first gene product and a second heterologous DNA encoding a second gene product. The first heterologous DNA is common to each member of the library, while the second heterologous DNA varies between members of the library. The present invention additionally provides a method of constructing a library of viral vectors. The method comprises carrying out homologous recombination between a first DNA molecule and a second DNA molecule to form a pool of intermediate viral vector genomes. One or more linear third DNA molecules are ligated into the pool of intermediate viral genomes to produce a library of viral vector genomes. Alternatively, homologous recombination between linear DNA molecules and recipient DNA molecules produces a library of viral vector genomes. The library of viral vector genomes is converted into a library of viral vectors.

Chimeric Vectors Comprising A Phage Packaging Site And A Portion Derived From The Genome Of A Eukaryotic Virus

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US Patent:
7070930, Jul 4, 2006
Filed:
Jun 3, 2002
Appl. No.:
10/162043
Inventors:
Duncan L. McVey - Derwood MD, US
Douglas E. Brough - Gaithersburg MD, US
Mohammed Zuber - Frederick MD, US
Imre Kovesdi - Rockville MD, US
Assignee:
GenVec, Inc. - Gaithersburg MD
International Classification:
C12Q 1/68
C12N 5/00
C12N 5/02
C12N 15/00
C12N 15/09
US Classification:
435 6, 435325, 4353201, 435477
Abstract:
The present invention provides an improved method of making eukaryotic gene transfer vectors comprising homologous recombining lambdid vectors with a second DNA in a bacterium to generate novel recombinant eukaryotic viral gene transfer vectors as well as a novel lambdid vector used in the inventive method and an inventive system comprising the novel lambdid vector.
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Duncan L Mcvey from Derwood, MD, age ~67 Get Report