Inventors:
Daniel Aeschlimann - Madison WI
Paul Bulpitt - Madison WI
Assignee:
Orthogene LLC - Sausalito CA
International Classification:
A61K 3800
US Classification:
514 54, 514 2, 514 8, 536 53, 435243, 4352536
Abstract:
Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, are biodegradable, and can serve as a tissue adhesive, a tissue separator, a drug delivery system, a matrix for cell cultures, and a temporary scaffold for tissue regeneration.