Christie G Enke

6452166, Sep 17, 2002

Apr 19, 2000

09/552646

Christie G. Enke - Albuquerque NM
George S. Jackson - Albuquerque NM

University of New Mexico - Albuquerque NM

H01J 3700

250288, 250423 R

An electrical equivalent circuit is provided for an electrospray process. It is a series circuit which includes a power supply voltage (V ), a voltage (V ) established at the electrochemical contact to the solution, a solution resistance (R ), a constant current regulator which represents the processes of charge separation and charge transport in the gap between the spray needle aperture and the counter electrode, and a voltage (V ) caused by charge neutralization at the counter electrode. A current i, established by the constant current regulator flows throughout the entire circuit. Current-voltage curves are developed for each part of the circuit. From these it is shown that in the case where R is negligible (the power supply is connected directly to a conducting needle) the shape of the current-voltage curve is dictated by the constant current regulator established by the charge separation process, the gap, and the counter electrode. The solution resistance is significant if a non-conducting needle is used so that the electrochemical contact to the solution is remote from the tip. The high series resistance acts to stabilize the operation of an electrospray ionization device enabling operation over a wider range of experimental conditions than without it.

6518569, Feb 11, 2003

Jun 9, 2000

09/591536

Jun Zhang - Albuquerque NM
Benjamin D. Gardner - Albuquerque NM
Christie G. Enke - Albuquerque NM

Science Technology Corporation UNM - Albuquerque NM

H01J 4900

250287, 250396 R

Novel ion mirrors comprising, in a preferred embodiment, three cylinders, rectangles or truncated cones to improve the resolving power in the time-of-flight mass spectrometers over broad ion kinetic energy ranges. The achieved electric field is non-linear along the mirror axis and relatively homogeneous in the mirror off-axis directions. Combined with dimension optimization, in a preferred embodiment, the adjustment of only two parameters of element voltages can yield preferred electric field distribution to fit different ion optical systems.

7041968, May 9, 2006

Mar 18, 2004

10/804968

Christie G. Enke - Placitas NM, US

Science & Technology Corporation @ UNM - Albuquerque NM

H01J 49/40

250282, 250281, 250287

A distance of flight (DOF) approach to mass spectrometry in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution element. The DOF mass spectrometer can serve as one element in a tandem arrangement which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A “distance-of-flight” (DOF) mass analyzer is used in combination with time-of-flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/z value from which each product ion m/z value emanated. Through the use of a two-dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.

7429728, Sep 30, 2008

Feb 23, 2006

11/360872

Christie G. Enke - Placitas NM, US

STC.UNM - Albuquerque NM

H01J 49/40

250282, 250281, 250287

A distance of flight (DOF) approach to mass spectroscopy in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution element. The DOF mass spectrometer can serve as one element in a tandem arrangement which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A “distance-of-flight” (DOF) mass analyzer is used in combination with time-of-flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/z value from which each product ion m/z value emanated. Through the use of a two-dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.

7947950, May 24, 2011

Oct 2, 2007

11/865812

Christie G Enke - Placitas NM, US
Gareth S Dobson - Burlingame CA, US

STC.UNM - Albuquerque NM

H01J 49/06
G01N 27/62

250290, 250281, 250282, 250288, 250291

A distance-of-flight mass spectrometer (DOF-MS) imparts constant momentum acceleration to ions in an ion source and uses an ion mirror to enhance energy focusing. Embodiments of DOF-MS with ion mirror are shown. Further, a method of compensating for the dispersion of initial ion position and velocity in the ion source is discussed.

7960692, Jun 14, 2011

May 24, 2007

11/753455

Gareth S. Dobson - Albuquerque NM, US
Christie G. Enke - Placitas NM, US

STC.UNM - Albuquerque NM

H01J 49/26
H01J 49/40

250283, 250281, 250282, 250287

A miniature linear ion trap (MLIT) with a length of less than 30 mm is provided for ion focusing in the axial plane. The MLIT has multipoles for applying an AC voltage to ions and tubular entrance and exit lenses for applying a DC voltage to the ions. In another aspect, MLIT includes electrodes within the tubular entrance and exit lenses for detection of image current. A method is also provided for applying voltage to the entrance and exit lenses for ion focusing.

8378296, Feb 19, 2013

Apr 5, 2011

13/080392

Christie Enke - Placitas NM, US

STC.UNM - Albuquerque NM

B01D 59/44
H01J 49/00

250288, 250281, 250282, 250284, 250286

Methods and instruments for high dynamic range analysis of sample components are described. A sample is subjected to time-dependent separation, ionized, and the ions dispersed with a constant integration time across an array of detectors according to the ions m/z values. Each of the detectors in the array has a dynamically adjustable gain or a logarithmic response function, producing an instrument capable of detecting a ratio of responses or 4 or more orders of magnitude.

8604423, Dec 10, 2013

Apr 5, 2011

13/639257

Christie G. Enke - Placitas NM, US
Steven J. Ray - Bloomington IN, US
Alexander W. Graham - Bloomington IN, US
Gary M. Hieftje - Bloomington IN, US
Elise Dennis - Bloomington IN, US
Charles J. Barinaga - West Richland WA, US
David W. Koppenaal - Richland WA, US

Indiana University Research and Technology Corporation - Indianapolis IN
Battelle Memorial Institute - Richland WA

H01J 49/26
H01J 49/40
B01D 59/44

250287, 250281, 250282, 250288, 31511161, 31511181

Novel methods and instrumentation for mass spectrometry are described. Zoom-time of flight mass spectrometry (Zoom-TOF) allows increased mass resolution over a pre-determined specific range of masses. Methods for retrofitting traditional time-of-flight (TOF) and distance of flight (DOF) mass spectrometers are described, as well as novel instruments capable of performing Zoom-TOF analyses.