US Patent:
20140147867, May 29, 2014
Inventors:
William D. Arnold - San Diego CA, US
Christelle Jost - San Diego CA, US
Brian Noland - Temecula CA, US
Jonathan Gary - San Diego CA, US
Joseph Buechler - Carlsbad CA, US
Vance Wong - Cardiff CA, US
Scott Harold Rongey - San Diego CA, US
Uday Kumar Veeramallu - San Diego CA, US
Kelline Marie Rodems - Oceanside CA, US
Assignee:
ALERE SAN DIEGO, INC. - San Diego CA
International Classification:
G01N 33/68
Abstract:
The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.
