Carl L Zwicker

20130089625, Apr 11, 2013

Sep 28, 2012

13/631732

Jean-Damien Charrier - Grove, GB
Pierre-Henri Storck - Abingdon, GB
John Studley - Witney, GB
Francoise Yvonne Theodora Marie Pierard - Abingdon, GB
Steven John Durrant - Abingdon, GB
Benjamin Joseph Littler - Carlsbad CA, US
Paul Angell - Carlsbad CA, US
Robert Michael Hughes - San Diego CA, US
David Andrew Siesel - San Diego CA, US
Armando Urbina - San Diego CA, US
Carl Zwicker - Brighton MA, US
Nicholas LoConte - Winthrop MA, US
Timothy Barder - Arlington MA, US

VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA

C07D 413/14
A61K 45/06
A61N 5/10
A61K 31/4745
A61K 31/7068
A61K 31/497
A61K 33/24

424649, 544405, 51425505, 514 49, 435184, 600 1

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I-1:wherein the variables are as defined herein.Additionally, the compounds of this invention have formula II:or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

20210047323, Feb 18, 2021

Aug 13, 2020

16/992441

- Boston MA, US
Kevin J. Gagnon - Acton MA, US
Jicong Li - Cambridge MA, US
Jennifer Lu - San Diego CA, US
Ales Medek - Winchester MA, US
Muna Shrestha - Belmont MA, US
Michael Waldo - Grafton MA, US
Beili Zhang - San Diego CA, US
Carl L. Zwicker - Wakefield MA, US
Corey Don Anderson - Brighton MA, US
Jeremy J. Clemens - San Diego CA, US
Thomas Cleveland - San Marcos CA, US
Timothy Richard Coon - Carlsbad CA, US
Bryan Frieman - La Jolla CA, US
Peter Grootenhuis - Del Mar CA, US
Sara Sabina Hadida Ruah - La Jolla CA, US
Jason McCartney - Cardiff by the Sea CA, US
Mark Thomas Miller - Rancho Santa Fe CA, US
Prasuna Paraselli - San Diego CA, US
Fabrice Pierre - La Jolla CA, US
Sara E. Swift - San Diego CA, US
Jinglan Zhou - San Diego CA, US

C07D 471/08

Crystalline forms of Compound I:pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

20210032255, Feb 4, 2021

Aug 17, 2020

16/994968

- Boston MA, US
Christopher John DAVIS - Salisbury, GB
Damien FRAYSSE - Abingdon, GB
Gorka ETXEBARRIA I JARDI - Abingdon, GB
Simon PEGG - Oxford, GB
Francoise PIERARD - Abingdon, GB
Joanne PINDER - Didcot, GB
John STUDLEY - Witney, GB
Carl ZWICKER - Brighton MA, US
Tapan SANGHVI - Watertown MA, US
Michael WALDO - Grafton MA, US
Ales MEDEK - Winchester MA, US
David Matthew SHAW - Oxford, GB
Maninder PANESAR - Didcot, GB
Yuegang ZHANG - Wayland MA, US
Naziha ALEM - Reading, GB

C07D 487/04
C07B 59/00
A61K 31/519
C07C 45/00
C07C 45/63

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B:wherein the variables are as defined herein.

20210009560, Jan 14, 2021

Mar 29, 2019

17/043217

- Boston MA, US
Mettachit NAVAMAL - Belmont MA, US
Kwame Wiredu NTI-ADDAE - Tewksbury MA, US
Yi SHI - Natick MA, US
Muna SHRESTHA - Belmont MA, US
Beili ZHANG - San Diego CA, US
Carl ZWICKER - Wakefield MA, US

C07D 401/14
C07D 401/04
A61P 11/00

Crystalline Forms of Compound (I); crystalline Forms of Compound (II) and crystalline forms of pharmaceutically acceptable salts of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

20190256516, Aug 22, 2019

Nov 15, 2018

16/192134

- Boston MA, US
Christopher John Davis - Salisbury, GB
Damien Fraysse - Abingdon, GB
Gorka Etxebarria I Jardi - Abingdon, GB
Simon Pegg - Oxford, GB
Francoise Pierard - Abingdon, GB
Joanne Pinder - Didcot, GB
John Studley - Witney, GB
Carl Zwicker - Brighton MA, US
Tapan Sanghvi - Watertown MA, US
Michael Waldo - Grafton MA, US
Ales Medek - Winchester MA, US
David Matthew Shaw - Oxford, GB
Maninder Panesar - Didcot, GB
Yuegang Zhang - Wayland MA, US
Naziha Alem - Reading, GB

C07D 487/04
C07B 59/00
C07C 45/63
C07C 45/00

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B:wherein the variables are as defined herein.

20150158872, Jun 11, 2015

Dec 5, 2014

14/561368

- Boston MA, US
Christopher John Davis - Salisbury, GB
Damien Fraysse - Abingdon, GB
Gorka Etxebarria I Jardi - Abingdon, GB
Simon Pegg - Oxford, GB
Francoise Pierard - Abingdon, GB
Joanne Pinder - Didcot, GB
John Studley - Witney, GB
Carl Zwicker - Brighton MA, US
Tapan Sanghvi - Watertown MA, US
Michael Waldo - Grafton MA, US
Ales Medek - Winchester MA, US
David Matthew Shaw - Oxford, GB
Maninder Panesar - Didcot, GB
Yuegang Zhang - Wayland MA, US
Naziha Alem - Reading, GB

C07D 487/04
C07C 45/63
C07C 45/00

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B:wherein the variables are as defined herein.