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Bradley Richard Nilsson

from Fitchburg, WI
Age ~50
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Also known as:
Bradley R Nilsson, Brad R Nilsson, Brad R Nilson
Related to:
Michael A Fober, 76Meta A NilssonSteven M Cahee, 55Kathryn M Greene, 54Michelle A Fober, 76Nelle G Greene, 88Charlotte J Fober, 76
Connected to:
Agneta E Nilsson, 84Blaine W Nilsson, 37Bud E Nilsson, 92Carsten D Nilsson, 57Dale E Nilsson, 61Darron L Nilsson, 47Denise A Nilsson, 69Eivor C Nilsson, 87Eleonor Nilsson, 36Eric D Nilsson, 57

Bradley Nilsson Phones & Addresses

  • Fitchburg, WI
  • 1517 Delaware Blvd, Madison, WI 53704 (608) 249-9002

Publications

Us Patents

Chemical Synthesis Of Reagents For Peptide Coupling

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US Patent:
6974884, Dec 13, 2005
Filed:
Jun 6, 2003
Appl. No.:
10/456988
Inventors:
Ronald T. Raines - Madison WI, US
Laura L. Kiessling - Madison WI, US
Bradley L. Nilsson - Madison WI, US
Yi He - Madison WI, US
Matthew B. Soellner - Madison WI, US
Ronald J. Hinklin - Longmont CO, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C07F005/02
US Classification:
568 2, 564123, 530402
Abstract:
The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.

Chemical Synthesis Of Reagents For Peptide Coupling

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US Patent:
7317129, Jan 8, 2008
Filed:
Sep 19, 2005
Appl. No.:
11/229926
Inventors:
Ronald T. Raines - Madison WI, US
Laura L. Kiessling - Madison WI, US
Bradley L. Nilsson - Madison WI, US
Yi He - Madison WI, US
Matthew B. Soellner - Madison WI, US
Ronald J. Hinklin - Longmont CO, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C07F 5/02
US Classification:
568 2, 564123, 530402
Abstract:
The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.

Ligation Method And Reagents To Form An Amide Bond

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US Patent:
20040087779, May 6, 2004
Filed:
Jan 23, 2003
Appl. No.:
10/276515
Inventors:
Ronald Raines - Madison WI, US
Laura Kiessling - Madison WI, US
Bradley Nilsson - Madison WI, US
International Classification:
C07K001/04
C07F009/28
US Classification:
530/409000, 562/008000
Abstract:
Methods and reagents for the formation of amide bonds between an activated carboxylic acid derivative and an azide useful in the synthesis of peptides, proteins and derivatized or labeled amino acids, peptide or proteins. The method involves the formation of a phosphinothioester which reacts with an azide resulting in amide formation. The invention provides phosphinothiol reagents which convert activated carboxylic acid derivatives to phosphinothioesters which then react with azides to form an amide bond. The methods and reagents of the invention can be used for stepwise synthesis of peptides on solid supports or for the ligation to two or more amino acids, two or more peptide or two or more protein fragments.
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Bradley Richard Nilsson from Fitchburg, WI, age ~50 Get Report