Barry E Kosofsky

20040029872, Feb 12, 2004

Feb 10, 2003

10/364303

Hans Breiter - Lincoln MA, US
Bruce Rosen - Lexington MA, US
John Marota - Boston MA, US
Joseph Mandeville - Somerville MA, US
Barry Kosofsky - Swampscott MA, US

The General Hospital Corporation, a Massachusetts corporation

A61K031/5415
A61K031/445
A61K031/485

514/225200, 514/317000, 514/282000

The invention provides methods for inhibiting psychostimulant-induced or nicotine-induced craving of additional psychostimulants (e.g., cocaine or amphetamine) or nicotine. In these methods, D1-like antagonists or D1-like agonists are administered to a patient dependent on psychostimulant drugs or nicotine and therefore susceptible to, or suffering from, such a craving. Also disclosed is an animal model system useful for measuring the ability of test compounds to inhibit psychostimulant-induced or nicotine-induced cravings in humans.

6517812, Feb 11, 2003

Sep 24, 1998

09/159659

Hans C. Breiter - Lincoln MA
Bruce R. Rosen - Lexington MA
John J. A. Marota - Boston MA
Joseph B. Mandeville - Somerville MA
Barry E. Kosofsky - Swampscott MA

The General Hospital Corporation - Boston MA

A61K 5100

424 92, 424 111, 424 165, 424 91

The invention provides methods for inhibiting psychostimulant-induced or nicotine-induced craving of additional psychostimulants (e. g. , cocaine or amphetamine) or nicotine. In these methods, D1-like antagonists or D1-like agonists are administered to a patient dependent on psychostimulant drugs or nicotine and therefore susceptible to, or suffering from, such a craving. Also disclosed is an animal model system useful for measuring the ability of test compounds to inhibit pyschostimulant-induced or nicotine-induced cravings in humans.

20200260997, Aug 20, 2020

May 8, 2020

16/870024

- Ithaca NY, US
Barry E. Kosofsky - New York NY, US

Cornell University - Ithaca NY

A61B 5/11
G06T 7/00
G06T 7/70
A61B 5/00

Tools and techniques for providing joint position error test system are provided. A system includes a head sensing unit coupled to a joint position error processor. The head sensing unit may include a positional sensor and further be configured to be coupled to the head of a test subject. The joint position error processor may include a processor, and non-transitory computer readable media comprising instructions executable by the processor to record reference sensor data from the positional sensor when the test subject's head is in a reference position, record return sensor data when the test subject's head is in a return position. The instructions may further be executable to determine a position error based on the reference sensor data and the return sensor data, and to further determine the presence of a condition of the test subject based on the position error.

20200100933, Apr 2, 2020

Dec 3, 2019

16/702232

- Ithaca NY, US
Barry Kosofsky - New York NY, US

Cornell University - Ithaca NY

A61F 7/00

The present disclosure describes systems and methods to non-invasively determine whether a patient has an autonomic dysfunction. In some implementations, the autonomic dysfunction can be a neurological dysfunction. The system can measure a patient's autonomic nervous system response to a stimulus. The stimulus can be a thermal stimulus, such as a cold temperature. The system can apply the thermal stimulus to an extremity of the patient, such as the patient's hand or arm.

20200022624, Jan 23, 2020

Jul 22, 2019

16/518526

- Ithaca NY, US
Barry E. Kosofsky - New York NY, US

Cornell University - Ithaca NY

A61B 5/11
G06T 7/00
G06T 7/70
A61B 5/00

Tools and techniques for providing joint position error test system are provided. A system includes a head sensing unit coupled to a joint position error processor. The head sensing unit may include a positional sensor and further be configured to be coupled to the head of a test subject. The joint position error processor may include a processor, and non-transitory computer readable media comprising instructions executable by the processor to record reference sensor data from the positional sensor when the test subject's head is in a reference position, record return sensor data when the test subject's head is in a return position. The instructions may further be executable to determine a position error based on the reference sensor data and the return sensor data, and to further determine the presence of a condition of the test subject based on the position error.