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Axel H Schonthal

from Los Angeles, CA
Age ~67
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Also known as:
Axel Dr Schonthal, Axel H Schoenthal, Axel L
Phone and address:
4040 Via Marisol, Los Angeles, CA 90042
Related to:
Jonathan Domingo, 31Eckert Nathalie S Schonthal, 33Tabitha R CunananJun R Conanan, 91Chelsy Cunanan, 31Jun R Cunanan, 63Alice M Cunanan, 65Victoriano R Cunanan, 68Florence C Domingo, 56Esther R Picache, 60Flor R Cunanan, 91Melissa Lester Cunanan, 56Flordeliza R Cunanan, 65Narciso C Cunanan
Connected to:
Susan R Schonthaler, 72Jeremy R Schonwald, 42Barbara J Schoo, 65Christopher L Schoo, 40Sherri K Schoo, 60Travis P Schoo, 44Brian F Schoof, 84Charles A Schoof, 42Cynthia Schoof, 59Darren P Schoof, 57

Axel Schonthal Phones & Addresses

  • 4040 Via Marisol, Los Angeles, CA 90042
  • 4040 Via Marisol #216, Los Angeles, CA 90042
  • 4300 Via Marisol UNIT 738, Los Angeles, CA 90042
  • 738 Fremont Villas #9, Los Angeles, CA 90042
  • 2011 Zonal Ave #405, Los Angeles, CA 90089
  • 12350 Del Amo Blvd #2009, Lakewood, CA 90715 (562) 803-3265

Work

Position: Professional/Technical

Education

Degree: Associate degree or higher

Publications

Us Patents

Methods And Compositions For Inducing Apoptosis By Stimulating Er Stress

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US Patent:
20090062227, Mar 5, 2009
Filed:
Mar 26, 2008
Appl. No.:
12/056192
Inventors:
AXEL H. SCHONTHAL - LOS ANGELES CA, US
NICOS A. PETASIS - HACIENDA HEIGHTS CA, US
FLORENCE M. HOFMAN - VENICE CA, US
STAN G. LOUIE - FULLERTON CA, US
THOMAS C. CHEN - LA CANADA CA, US
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA - LOS ANGELES CA
International Classification:
A61K 31/415
A61K 31/69
A61K 31/472
A61K 31/4418
A61K 31/427
A61K 31/496
A61K 31/7105
C40B 30/00
A61P 35/00
US Classification:
514 44, 514406, 514 64, 514307, 514357, 514365, 51425309, 506 7
Abstract:
The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.

Methods And Compositions For Inducing Apoptosis By Stimulating Er Stress

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US Patent:
20110318837, Dec 29, 2011
Filed:
Jun 14, 2011
Appl. No.:
13/160291
Inventors:
Axel H. SCHONTHAL - Los Angeles CA, US
Nicos A. PETASIS - Hacienda Heights CA, US
Florence M. HOFMAN - Venice CA, US
Stan G. LOUIE - Fullerton CA, US
Thonas C. CHEN - La Canada CA, US
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
International Classification:
C12N 5/071
US Classification:
435375
Abstract:
The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.

Methods And Compositions For Inducing Apoptosis By Stimulating Er Stress

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US Patent:
20160008378, Jan 14, 2016
Filed:
Feb 4, 2015
Appl. No.:
14/614362
Inventors:
- Los Angeles CA, US
Florence M. Hofman - Venice CA, US
Stan G. Louie - Fullerton CA, US
Thomas C. Chen - La Canada CA, US
Axel H. Schonthal - Los Angeles CA, US
International Classification:
A61K 31/635
A61K 38/05
A61N 5/10
A61K 31/4188
Abstract:
The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.

Methods And Compositions For Inducing Apoptosis By Stimulating Er Stress

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US Patent:
20140295549, Oct 2, 2014
Filed:
Dec 17, 2013
Appl. No.:
14/109731
Inventors:
- Los Angeles CA, US
Florence M. HOFMAN - Venice CA, US
Stan G. LOUIE - Fullerton CA, US
Thomas C. CHEN - La Canada CA, US
Axel H. SCHONTHAL - Los Angeles CA, US
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
International Classification:
A61K 31/415
A61K 38/00
US Classification:
435375
Abstract:
The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.

Compositions And Methods For Treating Brain Cancer

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US Patent:
20140288115, Sep 25, 2014
Filed:
Jun 6, 2014
Appl. No.:
14/298697
Inventors:
Thomas C. Chen - Los Angeles CA, US
Florence M. Hofman - Los Angeles CA, US
Stan G. Louie - Los Angeles CA, US
Axel H. Schonthal - Los Angeles CA, US
Nicos A. Petasis - Los Angeles CA, US
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
International Classification:
A61K 31/4741
A61N 5/10
C12Q 1/68
A61K 31/495
A61K 45/06
US Classification:
514291, 514393, 435375, 435 618, 600 1
Abstract:
It is discovered that noscapine is effective in treating temozolomide (TMZ)-resistant brain cancer. Provided are compositions and methods of treating brain cancer patients, in particular those that are TMZ-resistant. The patients are treated by administration of a therapeutically effective amount of noscapine or an analog thereof. In certain aspects, TMZ is also administered to the patients. Examples of brain cancers include glioma such as glioblastoma multiforme.
Control profile
Axel H Schonthal from Los Angeles, CA, age ~67 Get Report