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Arthur O Tzianabos

from Reading, MA
Age ~61
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Also known as:
Arthur D Tzianabos, Tzianabos O Arthur, Arthur S
Phone and address:
14 Duck Rd, Reading, MA 01867
(781) 942-2396
Connected to:
Christopher S Tzianabos, 59Golfo K Tzilos, 45Panagiotis Tzimas, 43Stavroula Tzimas, 53Timothy Tzimas, 56Aristotelis L Tzimoulis, 78Christos Tzimoulis, 48Harriet H Tzinakos, 54Angelo G Tzinares, 66Neil E Tzinberg, 69

Arthur Tzianabos Phones & Addresses

  • 14 Duck Rd, Reading, MA 01867 (781) 942-2396
  • 37 Hampshire Rd, Reading, MA 01867
  • Alton Bay, NH
  • Boston, MA
  • Melrose, MA
  • Dover, NH
  • Waban, MA

Resumes

Resumes

Arthur Tzianabos Photo 1

Sr. Vice President And Head, Research And Early Development At Shire

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Position:
Sr. Vice President and Head, Research and Early Development at Shire
Location:
Greater Boston Area
Industry:
Biotechnology
Work:
Shire - Lexington, MA since Feb 2013
Sr. Vice President and Head, Research and Early Development
Shire HGT Mar 2011 - Feb 2013
Vice President and Head, Research and Early Development
Shire HGT Dec 2008 - Apr 2011
Vice President, Program Management
Shire HGT Oct 2005 - Nov 2008
Sr. Director, Discovery Research
Harvard Medical School 1990 - 2005
Associate Professor of Medicine
Education:
Harvard Medical School 1990 - 1992
Post Doctoral Fellowship, Immunology University of New Hampshire 1985 - 1989
Ph D, Microbiology Boston College 1981 - 1985
Bachelor of Science (B.S.), Biology
Skills:
Lifesciences
Cross-functional Team Leadership
Clinical Development
Biotechnology
Drug Development
Pharmaceutical Industry
Drug Discovery
Regulatory Submissions
Biopharmaceuticals

Publications

Us Patents

Immunomodulating Polymers

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US Patent:
7026285, Apr 11, 2006
Filed:
May 19, 2004
Appl. No.:
10/848779
Inventors:
Arthur O. Tzianabos - Reading MA, US
Dennis L. Kasper - Charleston MA, US
Andrew B. Onderdonk - Westwood MA, US
Julia Ying Wang - Brookline MA, US
Assignee:
The Bingham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 47/36
A61K 47/42
US Classification:
514 2, 514 72, 424 9322, 4241921, 530530, 530402
Abstract:
Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.

Immunomodulating Polymers

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US Patent:
7083777, Aug 1, 2006
Filed:
Mar 31, 2000
Appl. No.:
09/540024
Inventors:
Arthur O. Tzianabos - Reading MA, US
Dennis L. Kasper - Charlestown MA, US
Andrew B. Onderdonk - Westwood MA, US
Ying Wang - Brookline MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 38/16
A61K 38/20
US Classification:
424 9322, 4241921, 530300, 530350, 5303783, 530 33, 530402, 514 2
Abstract:
A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the positively charged free amino moiety and the negatively charged moiety of each charge motif are separated by at least one neutral amino acid, and wherein the positively charged free amino moiety of one of the charge motifs is separated by a distance of at least 8 amino acids from the positively charged amino moiety of another charge motif, and a pharmaceutically acceptable carrier. Said pharmaceutical composition is useful for inducing IL-2, activating T cells to produce a T helper 1 cytokine profile, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and/or protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation.

Method For Overexpression Of Zwitterionic Polysaccharides

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US Patent:
7166455, Jan 23, 2007
Filed:
Mar 13, 2003
Appl. No.:
10/388390
Inventors:
Laurie E. Comstock - Medfield MA, US
Michael J. Coyne - North Attleboro MA, US
Dennis L. Kasper - Charlestown MA, US
Arthur O. Tzianabos - Reading MA, US
Katja G. Weinacht - Denzlingen, DE
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C12N 1/12
C12N 1/20
C12P 21/06
C12P 19/04
US Classification:
4352521, 4352523, 435 691, 435101
Abstract:
The present invention is directed to methods for producing and selecting novel mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.

Immunodulatory Compositions And Methods Of Use Thereof

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US Patent:
7456220, Nov 25, 2008
Filed:
Jul 7, 2005
Appl. No.:
11/176701
Inventors:
Pericles Calias - Melrose MA, US
Robert J. Miller - Halifax MA, US
Andrew B. Onderdonk - Westwood MA, US
Arthur O. Tzianabos - Reading MA, US
Assignee:
Genzyme Corporation - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 31/17
US Classification:
514588, 514825
Abstract:
The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment and prevention of diseases associated with inflammation and/or NOS.

Method For Overexpression Of Zwitterionic Polysaccharides

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US Patent:
7678558, Mar 16, 2010
Filed:
Jan 17, 2007
Appl. No.:
11/654246
Inventors:
Laurie E. Comstock - Medfield MA, US
Katja G. Weinacht - Denzlingen, DE
Michael J. Coyne - North Attleboro MA, US
Dennis L. Kasper - Charlestown MA, US
Arthur O. Tzianabos - Reading MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C12N 1/12
C12P 21/06
C12P 19/34
C12P 19/04
C12N 1/20
A01N 63/00
C07H 21/04
US Classification:
4352521, 4352523, 435 691, 435 911, 435101, 435183, 435221, 4352525, 4353201, 435471, 435476, 435477, 435490, 424 9346, 424 932, 424 931, 436 232
Abstract:
The present invention is directed to methods for producing and selecting novel mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.

Method For Overexpression Of Zwitterionic Polysaccharides

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US Patent:
7803602, Sep 28, 2010
Filed:
Aug 20, 2007
Appl. No.:
11/894552
Inventors:
Laurie E. Comstock - Medfield MA, US
Katja G. Weinacht - Denzlingen, DE
Michael J. Coyne - North Attleboro MA, US
Dennis L. Kasper - Charlestown MA, US
Arthur O. Tzianabos - Reading MA, US
Assignee:
The Brigham and Woman's Hospital, Inc. - Boston MA
International Classification:
C12N 1/20
C12N 15/87
C12N 15/74
C12P 21/06
C12P 19/04
C12P 19/34
A01N 63/00
US Classification:
4352523, 4352525, 435 691, 435101, 435 911, 4353201, 435471, 435476, 435477, 435490, 424 9346, 424 932, 424 931
Abstract:
The present invention is directed to methods for producing and selecting new mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.

Zwitterionic Immunomodulators For The Treatment Of Asthma And Allergy

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US Patent:
20040219160, Nov 4, 2004
Filed:
Mar 31, 2004
Appl. No.:
10/814620
Inventors:
Arthur Tzianabos - Reading MA, US
Dennis Kasper - Charlestown MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C12Q001/68
A61K039/00
A61K039/38
US Classification:
424/184100
Abstract:
Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic polymers which are found to induce certain T regulatory (Treg) cells and to exert immunosuppressive effects in vitro and in vivo.

Immunomodulating Polymers

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US Patent:
20060153832, Jul 13, 2006
Filed:
Mar 21, 2006
Appl. No.:
11/385111
Inventors:
Arthur Tzianabos - Reading MA, US
Dennis Kasper - Charlestown MA, US
Andrew Onderdonk - Westwood MA, US
Ying Wang - Brookline MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 39/395
US Classification:
424131100
Abstract:
Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
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Arthur O Tzianabos from Reading, MA, age ~61 Get Report