US Patent:
20230012262, Jan 12, 2023
Inventors:
- Foster City CA, US
Zhimin Du - Belmont CA, US
Julie Farand - San Mateo CA, US
Joshua A. Kaplan - Foster City CA, US
Barton W. Phillips - San Mateo CA, US
Doris T. Tang - Burlingame CA, US
Chandrasekar Venkataramani - San Carlos CA, US
Peiyuan Wang - San Mateo CA, US
Kin S. Yang - San Mateo CA, US
Anna Zagorska - Foster City CA, US
International Classification:
C07D 401/14
C07D 405/14
C07D 409/14
Abstract:
The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).