Resumes
Resumes
Albert Mach Phones & Addresses
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San Jose, CA
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Sunnyvale, CA
Publications
Us Patents
Method And Device For Isolating Cells From Heterogeneous Solution Using Microfluidic Trapping Vortices
View pageUS Patent:
20130171628, Jul 4, 2013
Filed:
Sep 12, 2011
Appl. No.:
13/823112
Inventors:
Dino Di Carlo - Los Angeles CA, US
Soojung C. Hur - Boston MA, US
Albert J. Mach - San Jose CA, US
Soojung C. Hur - Boston MA, US
Albert J. Mach - San Jose CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
C12Q 1/24
C12M 1/00
C12M 3/06
C12Q 1/68
G01N 33/58
C12M 1/00
C12M 3/06
C12Q 1/68
G01N 33/58
US Classification:
435 61, 435 30, 435 71, 4353091
Abstract:
A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at least one expansion region disposed along the length thereof. The at least one expansion region is an abrupt increase in a cross-sectional dimension of the at least one microfluidic channel configured to generate a vortex within the at least one expansion region in response to fluid flow. A solution containing a population of cells at least some of which have diameters ≧10 μm flows into the inlet. A portion of cells is trapped within vortex created within the at least one expansion region. The trapped cells may then released from the expansion region.
Method And Device For Isolating Cells From Heterogeneous Solution Using Microfluidic Trapping Vortices
View pageUS Patent:
20170114385, Apr 27, 2017
Filed:
Nov 7, 2016
Appl. No.:
15/345359
Inventors:
- Oakland CA, US
Soojung C. Hur - Boston MA, US
Albert J. Mach - San Jose CA, US
Soojung C. Hur - Boston MA, US
Albert J. Mach - San Jose CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
C12Q 1/24
G01N 33/50
B01L 3/00
C12M 1/00
C12M 3/06
G01N 1/40
G01N 33/58
G01N 33/50
B01L 3/00
C12M 1/00
C12M 3/06
G01N 1/40
G01N 33/58
Abstract:
A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at least one expansion region disposed along the length thereof The at least one expansion region is an abrupt increase in a cross-sectional dimension of the at least one microfluidic channel configured to generate a vortex within the at least one expansion region in response to fluid flow. A solution containing a population of cells at least some of which have diameters ≧10 μm flows into the inlet. A portion of cells is trapped within vortex created within the at least one expansion region. The trapped cells may then released from the expansion region.
Method And Device For Isolating Cells From Heterogeneous Solution Using Microfluidic Trapping Vortices
View pageUS Patent:
20160139015, May 19, 2016
Filed:
Nov 20, 2015
Appl. No.:
14/948119
Inventors:
- Oakland CA, US
Soojung C. Hur - Boston MA, US
Albert J. Mach - San Jose CA, US
Soojung C. Hur - Boston MA, US
Albert J. Mach - San Jose CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
G01N 1/40
G01N 33/50
G01N 33/50
Abstract:
A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at least one expansion region disposed along the length thereof. The at least one expansion region is an abrupt increase in a cross-sectional dimension of the at least one microfluidic channel configured to generate a vortex within the at least one expansion region in response to fluid flow. A solution containing a population of cells at least some of which have diameters ≧10 μm flows into the inlet. A portion of cells is trapped within vortex created within the at least one expansion region. The trapped cells may then released from the expansion region.
Devices And Methods For Dissociating A Biological Tissue Sample
View pageUS Patent:
20160069781, Mar 10, 2016
Filed:
Aug 4, 2015
Appl. No.:
14/817789
Inventors:
- Franklin Lakes NJ, US
Smita Ghanekar - Fremont CA, US
Brian David Warner - Martinez CA, US
Albert Mach - San Jose CA, US
David Vrane - San Jose CA, US
Smita Ghanekar - Fremont CA, US
Brian David Warner - Martinez CA, US
Albert Mach - San Jose CA, US
David Vrane - San Jose CA, US
International Classification:
G01N 1/28
Abstract:
Tissue dissociators configured to disrupt a biological tissue sample are provided. Aspects of the tissue dissociators may include a housing having a distal end and a proximal end, a cutting blade positioned at the distal end of the housing and a tissue actuator configured to be displaced along a longitudinal axis within the housing. Also provided are methods of using the tissue dissociators, as well as kits including the tissue dissociators.
Method And Device For Isolating Cells From Heterogeneous Solution Using Microfluidic Trapping Vortices
View pageUS Patent:
20150355060, Dec 10, 2015
Filed:
Aug 5, 2015
Appl. No.:
14/819302
Inventors:
- Oakland CA, US
Soojung C. Hur - Boston MA, US
Albert J. Mach - San Jose CA, US
Soojung C. Hur - Boston MA, US
Albert J. Mach - San Jose CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
G01N 1/40
G01N 33/50
G01N 33/50
Abstract:
A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at least one expansion region disposed along the length thereof. The at least one expansion region is an abrupt increase in a cross-sectional dimension of the at least one microfluidic channel configured to generate a vortex within the at least one expansion region in response to fluid flow. A solution containing a population of cells at least some of which have diameters ≧10 μm flows into the inlet. A portion of cells is trapped within vortex created within the at least one expansion region. The trapped cells may then released from the expansion region.
Microcuvette Cartridge
View pageUS Patent:
20140176939, Jun 26, 2014
Filed:
Dec 3, 2013
Appl. No.:
14/095971
Inventors:
- San Francisco CA, US
Albert Jerwen Mach - San Jose CA, US
Albert Jerwen Mach - San Jose CA, US
Assignee:
INTEGRATED PLASMONICS CORPORATION - San Francisco CA
International Classification:
G01N 21/03
US Classification:
356246
Abstract:
A microcuvette cartridge for optical measurement of a specimen includes: a substrate having a recess on an upper surface thereof to receive a fluid specimen therein, the substrate having a plurality of cavities therein to receive the fluid specimen transported from the recess, the substrate further defining a plurality of channels communicating with the recess and with the plurality of cavities, respectively, to transport the fluid specimen from the recess to the plurality of cavities, said substrate further having one or more of windows at positions corresponding to the plurality of cavities, the windows being transparent to wavelength of light with which the optical measurement is to be carried out so as to allow the light to interact with the fluid specimen in the cavities; and a transport mechanism to promote and complete flows of the fluid specimen from the recess to the plurality of cavities through the plurality of channels.